Psychiatry and Behavioral Health > Medication Resistant Depression and Anxiety

Medication Resistant Depression and Anxiety

Why choose Wayne Health for medication resistant depression and anxiety?

Wayne Health’s Psychiatry and Behavioral Health team focuses on caring for the total health of patients and the community-at-large. We’ve been a dedicated provider of behavioral health services for children, adolescents and adults since 1995.

Depression is no stranger to most. It is experienced by most people to some degree over the normal course of their lives and day-to-day living. Depression is synonymous with sadness, feeling down-hearted or bummed out, being down or blue, with low energy. There are different degrees of depression, including mild, moderate and severe, that are ranked based on several factors, including:

  • How long a person has experienced depressive feelings, thoughts and energy levels
  • The degree to which a person’s life is impacted in relation to family and friends
  • The degree to which participation in meaningful activities, such as work or school, is impacted

Depression is usually treated with a combination of antidepressant medication and certain types of therapy, including psychotherapy. For some, antidepressants provide relief without further interventions.

Depression that doesn’t respond to antidepressants is known as medication-resistant depression. Anxiety that doesn’t respond to medication, counseling and lifestyle changes may be medication- resistant anxiety.

Depression and anxiety can affect people differently and, if ignored, can lead to more serious issues. Please talk with your physician about your symptoms and options.

Wayne Health offers leading-edge treatments for medication-resistant depression and anxiety, including rapid-acting antidepressant medications and repetitive transcranial magnetic stimulation (rTMS). Any patient can ask to receive a specialized evaluation for these treatments.

Wayne Health medication resistant depression and anxiety services offered

  • Rapid-acting antidepressant medications
  • Psychotherapy or other cognitive behavioral therapies (CBT)
  • Repetitive transcranial magnetic stimulation (rTMS)
  • Transcranial direct current stimulation (tDCS)
  • Vagus nerve stimulation, by referral
  • Electroconvulsive therapy, by referral



Risk factors


Wayne Health's approach to treatment

Wayne Health is dedicated to educating patients about the treatment options available to treat medication-resistant depression and anxiety. We offer decision making aids that address the needs of individuals with different styles of selecting treatment options. This includes an information packet that describes the types of treatments and provides information regarding potential issues and concerns associated with those treatments. We use a collaborative process with each patient, coming to a shared plan that meets each individual’s unique needs. No treatment for medication-resistant depression and anxiety is provided without written consent of the patient and, if necessary, guardians or other personal supporters.


Antidepressant medicines may improve or completely relieve the symptoms of depression. Whether you need to take medicine depends on your symptoms. You and your doctor can decide if you need medicine and which medicine is right for you.

You may start to feel better within 1 to 3 weeks after you start taking antidepressant medicine. It can take as many as 6 to 8 weeks to see more improvement.


Counseling and psychotherapy are important parts of treatment for depression. You will work with a mental health professional such as a psychologist, licensed professional counselor, clinical social worker, or psychiatrist. Together you will develop an action plan to treat your depression.

Lifestyle changes

You can do many things to help yourself when you feel depressed or are waiting for your medicine to work. These things include being active, getting enough sleep, and eating a balanced diet.

Other treatment

Other treatments for depression include:

  • Brain stimulation. This includes:
    • Electroconvulsive therapy (ECT). Electrodes that produce a brief electrical stimulation to the brain are placed on the head. The stimulation produces a short seizure that is thought to balance brain chemicals.
    • Deep brain stimulation. A device that uses electricity to stimulate the brain is put in your head. It is used for Parkinson’s disease. But it has not been well studied for depression.
    • Vagus nerve stimulation. A generator the size of a pocket watch is placed in your chest. Wires go up from the generator to the vagus nerve in your neck. The generator sends tiny electric shocks through the vagus nerve to the brain.
    • Transcranial magnetic stimulation. An electromagnet is placed on your head. It sends magnetic pulses that stimulate your brain.
  • Complementary therapies. Always tell your doctor if you are using any of these types of therapies. They include:
    • Massage therapy, yoga, and other relaxation exercises.
    • Fish oil containing omega-3 fatty acids.
    • SAM-e (S-adenosylmethionine).


How is generalized anxiety disorder treated?

Counseling and medicine can both work to treat anxiety. The two are often used along with lifestyle changes.

Cognitive-behavioral therapy (CBT) is a type of counseling that’s used to help treat anxiety. In CBT, you learn how to notice and replace thoughts that make you feel worried. It also can help you learn how to relax when you worry.

Medicines can help. These medicines are often also used for depression. Selective serotonin reuptake inhibitors (SSRIs) are often tried first. But there are other medicines that your doctor may use. You may need to try a few medicines to find one that works well.

Many people feel better by getting regular exercise, eating healthy meals, and getting good sleep. Mindfulness—focusing on things that happen in the present moment—also can help reduce your anxiety.

Advancing research and medical education

Physicians and researchers at Wayne Health are also faculty members of the Wayne State University School of Medicine who conduct research and clinical studies. This makes the latest treatments and clinical trials available to you sooner than other health providers without a medical school affiliation. We are fully committed to innovative research that advances care and treatment in behavioral health.

For more information, please visit the links below at the WSU School of Medicine.